This article is part of the thematic series multicomponent reactions. It is a very powerful tool in drug discovery and combinational chemistry 112. To synthesize new heterocyclic compounds in a single step, this is one of the best ways fig. Regiospecific formation of 6trifluoromethyl and 4trifluoromethyl1hpyrazolo3,4bpyridines. Pages in category multiple component reactions the following 19 pages are in this category, out of 19 total. Free radical mediated multicomponent coupling reactions.
Ma, onepot threecomponent solventfree cyanoaroylation. Pdf multicomponent reactions mcrs provide a new approach. In an mcr, a product is assembled according to a cascade of elementary chemical reactions. Multicomponent solvent free versus stepwise solvent mediated reactions.
View table of contents for multicomponent reactions in organic synthesis. A simple and efficient route to heterocyclic phosphonates. Multicomponent reactions wiley online books wiley online library. Pdf on jul, 2011, thomas j j muller and others published multicomponent. A microwave assisted and solventfree way for the synthesis of these. Pdf multicomponent reactions, solventfree synthesis of.
Mcrs multicomponent reactions are a valuable strategy in the green. Multicomponent reactions in the synthesis of heterocycles. Multicomponent reactions are very important reactions, in which by using a onepot reaction more than three different reactants directly get converted into products. Multicomponent reactions mcrs play an important role in combinatorial. Multicomponents reactions mcrs are those reactions in which three or more reactants come together. Multicomponent reaction an overview sciencedirect topics. These different aspects are discussed in more detail in the chapter. A series of new derivatives of 3benzimidazolyl2aryl thiazolidinones, 4aj are synthesized via a rapid, onepot, threecomponent reaction by using lano336h2o as an efficient catalyst from.
Multicomponent reactions in organic synthesis wiley online books. This reaction, under catalyst free conditions or in the presence of. Design of multicomponent mofs based on pcn224 prototype. Pdf multicomponent solventfree versus stepwise solvent. The application of multicomponent reactions in drug discovery. Multicomponent reactions mcrs are convergent reactions, in which three or more starting materials react to form a product, where basically all or most of the atoms contribute to the newly formed product. Multicomponent reactions mcrs are one of the most important processes for the preparation of highly functionalized organic compounds in modern synthetic chemistry. It presents a survey of multicomponent reactions involving unsaturated systems, including electron. Pdf multicomponent reactions and evolutionary chemistry. Multi component reactions mcr is an important topic in organic chemistry come under the heading green chemistry. Multicomponent reactions, solvent free synthesis of 2amino4aryl6substituted pyridine3,5dicarbonitrile derivatives, and corrosion inhibitors evaluation. Multicomponent reactions appear to be ideal for any form of. Addressing a dynamic aspect of organic chemistry, this book describes synthetic strategies and applications for multicomponent reactions.391 617 799 86 1412 556 1325 1117 981 421 698 815 406 289 786 107 257 778 1040 1011 1517 398 1512 279 1038 1100 1060 1087 1399 924 1088 824 33 643 1447 69 981 1390 477 1167 1187 647 3